0000032198 00000 n Parenteral iron administration may be associated with hypersensitivity reactions [see Warnings and Precautions (5.1)], which may have serious consequences, such as fetal bradycardia (see Clinical Considerations). . General 3. Removal of Iron Dextran by Hemodialysis: An In Vitro Study. Each mL of iron dextran injection is equivalent of 50 mg of elemental iron. Unauthorized use of these marks is strictly prohibited. DOSAGE AND ADMINISTRATION Stability of aminophylline injection in three parenteral nutrient solutions. Administer the test dose at a gradual rate over at least 30 seconds into the buttock. 13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility Available data from postmarketing reports with iron dextran use in pregnancy are insufficient to assess the risk of major birth defects or miscarriage. All pregnancies have a background risk of birth defects, loss, or other adverse outcomes. Serum ferritin peaks approximately 7 to 9 days after an intravenous dose of Infed and returns to baseline after about 3 weeks. What are the possible side effects of INFeD? 0000039715 00000 n The easiest-to-prepare dilute solution (iron dextran, benzyl alcohol, and sterile water for injection) was stable for three months; stability was greater when refrigerated. Infed (iron dextran injection USP) is an iron replacement product provided as a dark brown, slightly viscous sterile liquid complex of ferric hydroxide and dextran for intravenous or intramuscular use. Allergan USA, Inc. HONcode standard for trust- worthy health, 7 Natural Remedies for Rheumatoid Arthritis, How Prenatal Counseling Can Help You Through Pregnancy, Parenteral iron treatment should be administered only when, Milliliter Requirement of INFeD Based On Observed. .12.0 g/dl, c. Iron content of hemoglobin . PDF Storage and Reuse of Reconstituted Neuromodulators 0000001071 00000 n 4GWVI~p`1x_7G|_Wz/ev5%b[~?w>ZG/*p%\/??w~=+ |O?~po>u|.@uM=Nvm_~~>\.%>?_mk+mp_{"ly"Y{JlqgIl#Y!Y@osLu]Mt=xx? Gaithersburg, MD: Genzyme; August 2018. Additionally, concomitant use of angiotensin-converting enzyme inhibitor drugs may increase the risk for reactions to an iron dextran product. Clinical Considerations The following information about each drug is given in tabular format: drug to be reconstituted and size of package; recommended route(s) of administration; recommended diluent, quantity to be used and resultant concentration; 1-800-678-1605, Manufactured By: 2.4 Administration Ferric carboxymaltose is a colloidal iron (III) hydroxide in complex with carboxymaltose, a carbohydrate polymer that releases iron. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. 0000014709 00000 n Fetal/Neonatal Adverse Reactions III. I. Respiratory, thoracic and mediastinal disorders: Respiratory arrest, dyspnea, bronchospasm, wheezing. If diluted, administer by IV infusion [off-label] over 16 hours. Importance of informing clinicians of existing or contemplated concomitant therapy, including prescription and OTC drugs, as well as concomitant illnesses. 1984 Mar;19(3):202, 207, 211-3. Prior to the first intramuscular Infed therapeutic dose, administer an intramuscular test dose of 0.5 mL [see BOXED WARNING and Warnings and Precautions (5.1)]. Sodium hydroxide and/or hydrochloric acid may have been used to adjust pH. Recommended dosage for treatment of iron deficiency anemia also may be determined from a table; consult manufacturers labeling. The total amount of INFeD in mL required to treat the anemia and replenish iron stores may be approximated as follows: Adults and Children over 15 kg (33 lbs): See Dosage Table. 34 55 Table 1: Total Infed Requirement for Hemoglobin Restoration and Iron Stores Replacement in Patients with Iron Deficiency Anemia*. . 0000003746 00000 n government site. For solution and drug compatibility information, see Compatibility under Stability. The extent of risk for anaphylactic-type reactions following exposure to any specific iron dextran product is unknown and may vary among the products. Brand names: Dexferrum, INFeD Bethesda, MD 20894, Web Policies Excessive dosages of Infed may lead to accumulation of iron in storage sites potentially leading to hemosiderosis. . Administer a test Infed dose prior to the first therapeutic dose. Patients with a history of drug allergy or multiple drug allergies may be at increased risk of anaphylactic-type reactions to Infed. Excessive therapy with parenteral iron can lead to excess storage of iron with the possibility of iatrogenic hemosiderosis. In vitro studies have shown that removal of iron dextran by dialysis is negligible. Unable to load your collection due to an error, Unable to load your delegates due to an error. 5 If reconstituted vaccine is not used immediately or comes in a multidose vial, be sure to clearly mark the vial with the date and time the vaccine was reconstituted, maintain the product at 2-8C (36-46F); do not freeze, and use only within the time indicated on chart above. Although anaphylactic reactions known to occur following INFeD administration are usually evident within a few minutes, or sooner, it is recommended that a period of an hour or longer elapse before the remainder of the initial therapeutic dose is given. Infed (iron dextran injection), for intravenous or intramuscular use (5.1) endobj 12.1 Mechanism of Action Please refer to the ASHP Drug Shortages Resource Center for information on shortages of one or more of these preparations. Following administration of Infed, circulating iron dextran is split by the cells of the reticuloendothelial system into its components of iron and dextran. For full access to this pdf, sign in to an existing account, or purchase an annual subscription. Administer undiluted by slow (50 mg/minute) IV injection; some preparations (i.e., INFeD) also are FDA-labeled for IM injection. The total amount of INFeD required for the treatment of iron deficiency anemia or iron replacement for blood loss is determined from the table or appropriate formula (See Dosage). The following clinically significant adverse reactions are described elsewhere in the labeling: Blood and lymphatic system disorders: Leukocytosis, lymphadenopathy. The pH of the solution is between 4.5 to 7.0. Bone scans involving 99m Tc-diphosphonate have been reported to show a dense, crescentic area of activity in the buttocks, following the contour of the iliac crest, 1 to 6 days after intramuscular injections of Infed. 0000031965 00000 n Dilution not recommended by manufacturers, but there have been reports of the total calculated dose of iron dextran being diluted in 2501000 mL of 0.9% sodium chloride injection for IV infusion [off-label]. Possible increased incidence of gram-negative sepsis; not recommended for use in infants <4 months of age. A.YGtT~Ud!$8 d|Ey[9l]^Z.d,{Ah>=1LfC6= Lc3I`hOf2!*sXk!dPz9.UZJe|6xsd_nMS]UYG4@GCj_'8m$7$U |_6%$yf endobj Iron Dextran (INFeD or DexFerrum ) INFeD and DexFerrum are iron dextran pro-ducts marketed in the United States. . The stability of injectable medications after reconstitution is presented. <> The etiology of these reactions is not known. 0000002441 00000 n Bone scans with 99m Tc-labeled bone seeking agents, in the presence of high serum ferritin levels or following Infed infusions, have been reported to show reduction of bony uptake, marked renal activity, and excessive blood pool and soft tissue accumulation. COMMENTARY Biological parenteral products ar - American Society of 0000003347 00000 n The maximum daily dose of INFeD should not exceed 2 mL. Should be administered by qualified individuals with ready access to resuscitation equipment and appropriate agents for the treatment of a severe allergic or anaphylactic reaction (e.g., epinephrine, or isoproterenol in patients receiving -adrenergic blocking agents). 1995; 26(2):327-330. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. 88 0 obj<>stream Have resuscitation equipment and personnel trained in the detection and treatment of anaphylactic-type reactions readily available during Infed administration. tran [6]. 4. Animal Data *Table values were calculated based on a normal adult hemoglobin of 14.8 g/dl for weights greater than 15 kg (33 lbs) and a hemoglobin of 12.0 g/dl for weights less than or equal to 15 kg (33 lbs). CAS number: 9004-66-4. PDF HIGHLIGHTS OF PRESCRIBING INFORMATION ZEPZELCA, periodically during The table and formula described under I.Iron Deficiency Anemia are not applicable for simple iron replacement values. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever the solution and container permit. Y-site compatibility of medications with parenteral nutrition. Individual doses of 2 mL or less may be given on a daily basis until the calculated total amount required has been reached. . xb```f``= @Q#3108-. Unable to load your collection due to an error, Unable to load your delegates due to an error. RRd::||7?_EeYU2&*[-%yWU0J@eZZ+)_P2B A_`T Unwarranted therapy with parenteral iron will cause excess storage of iron with the consequent possibility of exogenous hemosiderosis. 15 kg (33 lbs) or less . Delayed Reactions 0000002644 00000 n Following intramuscular injection, Infed is absorbed within 72 hours with any remaining iron absorbed over the ensuing 3 to 4 weeks. Chemical and physical bases determining the instability and incompatibility of formulated injectable drugs. Nephron. PMC Absorbed slowly from the site of IM injection, principally through the lymphatic system; 60% of an IM dose after 3 days, up to 90% after 13 weeks; and the remainder gradually absorbed over a period of several months or longer. Advise patients with pre-existing cardiovascular disease and rheumatoid arthritis that Infed administration may exacerbate symptoms and to contact their healthcare provider if any symptoms occur [see Warnings and Precautions (5.3)]. 8.2 Lactation 1 0 obj To avoid injection or leakage into the subcutaneous tissue, a Z-track technique (displacement of the skin laterally prior to injection) is recommended. Large intravenous doses, such as used with total dose infusions (TDI), have been associated with an increased incidence of adverse reactions. I. Infed is indicated for treatment of adult and pediatric patients of age 4 months and older with documented iron deficiency who have intolerance to oral iron or have had an unsatisfactory response to oral iron. General considerations, the nitrosoureas and alkylating agents. . 0000002918 00000 n Therapy, thus, should aim at not only replenishment of hemoglobin iron but iron stores as well. Package insert / product label May also be given IM or slow IVP (1 ml/min x 2 min = 100 mg). For all medical inquiries contact: ], Observed Hb = the patients current hemoglobin in g/dL. Off-label: Use is not currently included in the labeling approved by the US Food and Drug Administration. Search for other works by this author on: Copyright 1976, American Society of Hospital Pharmacists, Inc. All rights reserved. endstream endobj 48 0 obj<> endobj 49 0 obj<> endobj 50 0 obj<> endobj 51 0 obj<>stream TVFRk-ijJ>r$QK{\[8 `v,heF-ZQ4R70rj !sGE In doses 500 mg, iron dextran plasma concentrations decrease exponentially with a half-life of about 6 hours. .14.8 g/dl If no adverse reactions are observed, INFeD can be given according to the following schedule until the calculated total amount required has been reached. Infed is not recommended for use in infants under 4 months of age [see Dosage and Administration (2.2)]. The following information about each drug is given in tabular format: drug to be reconstituted and size of package; recommended route(s) of administration; recommended diluent, quantity to be used and resultant concentration; stability after initial dilution; and stability after further dilution; and stability of frozen antibiotics. (5.3). Distributed into milk (as traces of unmetabolized iron dextran); use with caution in nursing women. A subsidiary of Watson Pharmaceuticals, Inc. It should be remembered that iron deficiency anemia will not appear until essentially all iron stores have been depleted. e. Weight. The site is secure. Medical Communications Adverse pregnancy outcomes associated with IDA include increased risk for preterm delivery and low birth weight. Fetal and maternal toxicity has been reported in monkeys at a total intravenous dose of 90 mg iron/kg over a 14 day period. . After reticuloendothelial cells separate iron from the iron dextran complex, iron becomes a part of the bodys total iron stores. FOIA 0000003708 00000 n 0000036574 00000 n Skin and subcutaneous disorders: Urticaria, pruritus, purpura, rash, sweating. Advise the patient to consult a healthcare provider before taking any other iron containing products as this may cause serious side effects [see Warnings and Precautions (5.4)]. 0000000016 00000 n CAREFULLY BEFORE ACCESSING OR USING THIS SITE. The .gov means its official. The stability of injectable medications after reconstitution is presented. Do Not Copy, Distribute or otherwise Disseminate without express permission. Excretion If the patient is standing, he/she should be bearing his/her weight on the leg opposite the injection site, or if in bed, he/she should be in the lateral position with injection site uppermost. % %PDF-1.3 % Your comment will be reviewed and published at the journal's discretion. ~q`C34&rAd oG If no manifestations of anaphylactic-type reactions occur after test dose, administer full therapeutic dose. Risk Summary 0000003686 00000 n a. . This total iron requirement reflects the amount of iron needed to restore hemoglobin concentration to normal or near normal levels plus an additional allowance to provide adequate replenishment of iron stores in most individuals with moderately or severely reduced levels of hemoglobin. After reconstitution with 19 ml water for injections, the product contains 10 mg/ml voriconazole and 160 mg/ml SBECD. INFeD should be used with caution in individuals with histories of significant allergies and/or asthma. Hilleman DE, McEvoy GK, Bailey RT Jr, Reich J. Hosp Pharm. . 0000009088 00000 n . endstream endobj 47 0 obj<>stream BILy@yK5] I(Y+ u YV ;bPqZ9~3oG RqK|"@k!/<9 .*JIr|R$ck4w8Szd*-qK"#AgFIyVsT`PtP_-tO=jq"~.^^2={nZU$ , INFeD should be injected only into the muscle mass of the upper outer quadrant of the buttock - never into the arm or other exposed areas - and should be injected deeply, with a 2-inch or 3-inch 19 or 20 gauge needle. The test dose should be administered in the same recommended test site and by the same technique as described in the last paragraph of this section. For information on systemic interactions resulting from concomitant use, see Interactions. 0000003396 00000 n Delay administration of the initial therapeutic Infed dose until 1 hour or more after the test dose. 0000035990 00000 n An official website of the United States government. TRW3xs6's;W2YK8AAv4Qo~S ONW>dVN--sFhQe@ 0{7;;vmG+zW%Rmhh_}m?rjnY'0_i' C?U"-DA('[ Watson Pharma, Inc. PDF 1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE - Allergan The following adverse reactions associated with the use of Infed were identified in clinical studies or postmarketing reports. 0000004715 00000 n 2009 Jan;14(1):48-56. doi: 10.5863/1551-6776-14.1.48. government site. endstream endobj 52 0 obj<> endobj 53 0 obj<> endobj 54 0 obj<>stream Do not mix with other drugs or add to parenteral nutrition solutions for IV infusion. Administer the test dose at a gradual rate over at least 30 seconds. Use the following formula to calculate required total iron dextran dosage in mL: 0.02 blood loss (in mL) hematocrit (expressed as a decimal fraction) = total dosage of iron dextran injection (mL). LBW = Lean body weight in kg. 0000010759 00000 n Drug interactions involving Infed have not been studied. Anaphylaxis and other hypersensitivity reactions have been reported after uneventful test doses as well as therapeutic doses of iron dextran injection. 0000009371 00000 n Bullock L, Parks RB, Lampasona V, Mullins RE. Possible fever and exacerbation or reactivation of joint pain and swelling with IV administration in patients with rheumatoid arthritis; use with extreme caution. Madison, NJ 07940. Adverse reactions experienced following administration of Infed may exacerbate cardiovascular complications in patients with pre-existing cardiovascular disease. (Normal Hb for Children 15 kg or less is 12 g/dl). Generic name: iron dextran Administer test dose by intended route of administration for therapeutic doses prior to initial therapeutic dose. 1 INDICATIONS AND USAGE INFeD is indicated for treatment of adult and pediatric patients of age 4 months and older with documented iron deficiency who have intolerance to oral iron or have had an unsatisfactory response . . 1983 Jan 1;286(6358):32-6. doi: 10.1136/bmj.286.6358.32. Department of Pharmacy, Ohio State University Hospitals, Columhus 43210. Children 5 - 15 kg (11 - 33 lbs): See Dosage Table. Although there are significant variations in body build and weight distribution among males and females, the accompanying table and formula represent a convenient means for estimating the total iron required. INFeD, Dexferrum (iron dextran complex) dosing, indications - Medscape 8.4 Pediatric Use over 15 kg (33 lbs) . "VIz h\["2[4p))zE.gggvY?D2$NB2+t*6-yEqK $iFV].o =6LyG)5"S t.?aA@pt4y!#4^R(3qCY#D The physicochemical and mi-crobiological qualities of biological products are functions of the aseptic An official website of the United States government. Each days dose should ordinarily not exceed 0.5 mL (25 mg of iron) for infants under 5 kg (11 lbs); 1.0 mL (50 mg of iron) for children under 10 kg (22 lbs); and 2.0 mL (100 mg of iron) for other patients. HOW SUPPLIED p?kh|*rB vg8Si*-T+/_VHEbT!AlK*3 (See package insert for PRECAUTIONS: Pediatric Use), Alternatively the total dose may be calculated: This antibiotic is active against Gram-positive aerobic and anaerobic bacteria1 2 and is commonly used in hospitals to treat serious infections.3 4 Vancomycin has slow bactericidal time-dependent activity and can be administered by continuous or . 0000026943 00000 n Table 1: Total Infed Requirement for Hemoglobin Restoration and Iron Stores Replacement in Patients with Iron Deficiency Anemia* Alternatively, the total dose may be calculated using the formulas below: Adults and Children over 15 kg (33 lbs) Dose (mL) = 0.0442 (Desired Hb - Observed Hb) x LBW + (0.26 x LBW) Based on: sharing sensitive information, make sure youre on a federal If no adverse reactions are observed, Infed can be given according to the following schedule until the calculated total required dose has been reached. Oral iron should be discontinued prior to administration of INFeD. "3#$-Irc8x=B_}>_W@HqAP!I`H9+.@F.ix;i1E]"EOQ4E7M9$PB em$ Ie2} %+}hIIU}E+rS_OENx(tF_)@nRAtZn#JHg221^m+U|"vy ]yakuU The molecular weights of INFeD and DexFerrum are 165,000 and 267,000 daltons, respectively. 0000002041 00000 n II. 1986;17(1):1-10. doi: 10.1007/BF00299858. 0000002294 00000 n 0000008617 00000 n <> 0000008494 00000 n [qsXBp^z\}L88l$ 6 v~\^bdQl=;GmC;c}_6u6bMUb#&YlKS;ii.HGaToD7Wg%.[vIo6y/tIiVool#8is?8dK After slow IV injection (given over 30 seconds for INFeD or 5 minutes for Dexferrum) or IM injection (INFeD) of 25 mg of iron (0.5 mL), observe for 1 hour for sensitivity reactions (see Anaphylaxis under Cautions) before administering the remaining portion of the initial dose. HlTM6(R;!$+g}4h*I:-~`wIg;g5#I:X3Gs3dlg7E%~KyV0=^z@X,/%OE9oCz?=P%!XYUX8]hMW;2m%}?={ Pov5J%3LaA@a9"099^eiqk5r#ZH34`&`Eaj,@6kbBQ(BPt"`32n'OV4=:yOM2hf}"V@> Therefore, administration of subsequent test doses during therapy should be considered. trailer << /Size 254 /Info 216 0 R /Root 219 0 R /Prev 331519 /ID[<618a70ff49b482af49be42cc5de1ac5d><4f4e9802b6496a1513efa6cfdffb7212>] >> startxref 0 %%EOF 219 0 obj << /Type /Catalog /Pages 213 0 R /Metadata 217 0 R /PageLabels 211 0 R >> endobj 252 0 obj << /S 769 /T 901 /L 982 /Filter /FlateDecode /Length 253 0 R >> stream Take precautions to be prepared to treat potential allergic reactions. Each monograph contains stability data, administration guidelines, and methods of preparation. Corrections in compilation of information on stability of injectable medications after reconstitution. WARNING: RISK FOR ANAPHYLACTIC-TYPE REACTIONS (Usual adult dose: 0.5 mL of a 1:1000 solution, by subcutaneous or intramuscular injection.). During all Infed administrations, observe for signs or symptoms of anaphylactic-type reactions. . endobj Please check for further notifications by email. (See Boxed Warning.) This site needs JavaScript to work properly. [See USP Controlled Room Temperature]. 0000008737 00000 n trailer The circulating iron is bound to the available protein moieties to form hemosiderin or ferritin, or to a lesser extent to transferrin. Large doses of iron dextran (5 mL or more) have been reported to give a brown color to serum from a blood sample drawn 4 hours after administration. Abstract. INDICATIONS AND USAGE: Injectafer is indicated for the treatment of iron deficiency anemia in adult patients: >who have intolerance to oral iron or have had unsatisfactory response to oral iron; 0000006734 00000 n INFeD belongs to a class of drugs called Iron Products. Although serum ferritin is usually a good guide to body iron stores, the correlation of body iron stores and serum ferritin may not be valid in patients on chronic renal dialysis who are also receiving iron dextran complex. Serum iron, total iron binding capacity (TIBC) and percent saturation of transferrin are other important tests for detecting and monitoring the iron deficient state. Improper storage conditions after reconstitution will lead to the administration of a subtherapeutic medication and will eventually lead to treatment failure and antibiotic resistance. J Pediatr Pharmacol Ther. Advise pregnant persons about the risk of hypersensitivity reactions which may have serious consequences for the fetus [see Use in Specific Populations (8.1)]. 0000003913 00000 n The 20 hour value reflects a half-life determined by measuring total 59Fe, both circulating and bound. W = body weight in kg Therefore, administration of subsequent test doses during therapy should be considered. Based on the above factors, individuals with normal hemoglobin levels will have approximately 33 mg of blood iron per kilogram of body weight (15 mg/lb). Initial U.S. Approval: 1974 Use of 5% dextrose injection instead of 0.9% sodium chloride injection may be associated with a higher incidence of local pain and phlebitis. For females: LBW = 45.5 kg + 2.3 kg for each inch of patients height over 5 feet KAAtAP%$ 1GvuK h|Sqm!5x:9>{HBBL9x`:}R/{H$\SRH'yVf3g1EG5=p2a[\K5E:/mV: T1 During administration of any iron dextran dose, observe for manifestations of anaphylactic-type reactions. 2021 Allergan. Such blood losses may occur periodically in patients with hemorrhagic diatheses (familial telangiectasia; hemophilia; gastrointestinal bleeding) and on a repetitive basis from procedures such as renal hemodialysis. Importance of women informing their clinician if they are or plan to become pregnant or plan to breast-feed. 0000013948 00000 n Cancer Chemother Pharmacol. endstream endobj 35 0 obj<> endobj 36 0 obj<> endobj 37 0 obj<>/Font<>/ProcSet[/PDF/Text]/ExtGState<>>> endobj 38 0 obj<> endobj 39 0 obj<> endobj 40 0 obj<> endobj 41 0 obj<> endobj 42 0 obj<> endobj 43 0 obj[/ICCBased 66 0 R] endobj 44 0 obj<> endobj 45 0 obj<>stream 16.2 Stability and Storage '* stream 0000013099 00000 n For males: LBW = 50 kg + 2.3 kg for each inch of patients height over 5 feet CONTRAINDICATIONS Each monograph contains stability data, administration guidelines, and methods of preparation. Written by ASHP. Iron dextran has been shown to be teratogenic and embryocidal in mice, rats, rabbits, dogs, and monkeys when given in doses of about 3 times the maximum human dose. Disclaimer. Am J Kid Dis. . Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. <> Distributed into breast milk, but only as trace amounts of unmetabolized iron dextran. All Rights Reserved. 0000003224 00000 n INFeD may be used alone or with other medications. David McAuley, Pharm.D. INFeD (IRON DEXTRAN COMPLEX) INJECTION SDS EFFECTIVE DATE: SEPTEMBER 24, 2018 PAGE 1 OF 8 SAFETY DATA SHEET Prepared to U.S. OSHA, CMA, ANSI, Canadian WHMIS Standards, European Union CLP EC 1272/2008 and the Global Harmonization Standard 1. To calculate a patient's weight in kg when lbs are known: 2.3 Recommended Dosage of Iron Replacement for Blood Loss 0000047340 00000 n There have been several reports in the literature describing tumors at the injection site in humans who had previously received intramuscular injections of iron-carbohydrate complexes. Data sources include IBM Watson Micromedex (updated 2 Apr 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. THE TEST DOSE SHOULD BE ADMINISTERED AT A GRADUAL RATE OVER AT LEAST 30 SECONDS. The product should be further diluted in a suitable diluent prior to infusion. 0000012898 00000 n Stability of acyclovir sodium after reconstitution in 0.9% sodium chloride inje ction and storage in polypropylene syringes for pediatric use. . Concomitant use of angiotensin-converting enzyme inhibitor drugs may increase the risk for anaphylactic-type reactions to an iron dextran product. Brand and Other Names: INFeD, Dexferrum Classes: Iron Products Dosing & Uses AdultPediatric Dosage Forms & Strengths injectable solution 50mg (Fe)/mL Iron-deficiency Anemia 25-100 mg IV or deep. Int J Pharm Compd. 0000026302 00000 n Untreated iron deficiency anemia (IDA) in pregnancy is associated with adverse maternal outcomes such as post-partum anemia. In patients with chronic kidney disease (CKD) on hemodialysis, IV iron superior to orally administered iron for increasing hemoglobin concentrations and/or minimizing dosage of an erythropoiesis-stimulating agent (ESA); the National Kidney Foundation Kidney Disease Outcomes Quality Initiative (NKF-KDOQI) guidelines state that the IV route is preferred for iron administration in such patients. Sensitivity (e.g., anaphylactoid or anaphylactic) reactions, including fatalities, have occurred following parenteral administration of iron dextran. Does not stimulate erythropoiesis nor does it correct hemoglobin disturbances not caused by iron deficiency. . The amount of vancomycin to treat an adult infection is superior to 1 g and so the volume administered can be higher than 100 mL. Available as iron dextran; dosage expressed in terms of elemental iron.
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