Thyroxine (T4) and triiodothyronine (T3) are primary thyroid hormones that affect all of your bodys cells. Try our Symptom Checker Got any other symptoms? These three factors are important in understanding how methimazole can lead to weight gain in certain people. A Community for those living with and dealing with Graves' Disease. No evidence of vasculitis or parasites was seen. If you take these medications at the same time as your thyroid medication, it can interfere with how well it works. The onset of aplastic anemia (pancytopenia) or agranulocytosis may occur in hours to days. The doctor will diagnose you and recommend the next step. A common symptom of hyperthyroidism is weight loss without trying. R Bou Khalil and M Abou Salbi were involved in data collection, patient care, and follow-up. Home Patients Portal Clinical Thyroidology for the Public March 2020 Vol 13 Issue 3 p.3-4, Summaries for the Public from recent articles in Clinical Thyroidology effects. Thus, it is considered a thyroid blocking agent. Use of the forums is subject to our Terms of Use The https:// ensures that you are connecting to the Our clinical information meets the standards set by the NHS in their Standard for Creating Health Content guidance. We present a case of myositis in a hyperthyroid patient that started shortly after initiating methimazole and resolved after its withdrawal, with a biopsy-proven eosinophilic myositis and lack of vasculitis. #1. https://www.ncbi.nlm.nih.gov/pubmed/24692351, #2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2817786/, #3. https://www.ncbi.nlm.nih.gov/gene/7173, #4. https://www.ncbi.nlm.nih.gov/pubmed/28759749, #5. https://www.ncbi.nlm.nih.gov/pubmed/22990640, #6. https://www.ncbi.nlm.nih.gov/pubmed/19341475, #7. https://www.ncbi.nlm.nih.gov/pubmed/19432125, #8. https://www.ncbi.nlm.nih.gov/pubmed/11531931, #9. https://www.ncbi.nlm.nih.gov/pubmed/12939927. It is caused by antibodies that attack the thyroid and turn it on. A total of 65% of patients gained 5% of their weight and 38% gained 10% or more. In our case, the patient could have drug-induced lupus as shown by the positive anti-double-stranded DNA but the marked eosinophilia, the presence of eosinophilic myositis, and the absence of vasculitis on biopsy pointed toward a different mechanism responsible for the myositis than a simple drug-induced lupus. Felimazole (methimazole) is the only drug approved to treat the disease in cats. But, on the other hand, we also want to balance thyroid hormone to prevent weight gain, depression and cholesterol issues (all side effects and symptoms of hypothyroidism or an indication that your body is swinging from hyperthyroidism to hypothyroidism). Certain diseases are particularly dangerous and harm our bodies in other ways. Other rare features are hypereosinophilic syndrome characterized by hypereosinophilia with multisystem involvement and idiopathic eosinophilic myositis (Table 2). Have you been able to lose weight despite it being difficult? You should not breast-feed while using methimazole. The latter, however, does not explain the eosinophilic myositis nor the associated fasciitis. Seven out of 10 people in the U.S. are overweight, many carrying belly fat that is difficult to shed. Data sources include IBM Watson Micromedex (updated 1 May 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. #4. I lost 5 pounds in 3 days, not doing any exercise and eating regularly. These side effects may go away during treatment as your body adjusts to the medicine. Side effects that you should report to your care team as soon as possible: Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome): This list may not describe all possible side effects. Protect from light. So if you are on these medications you will need to take a close look at your current dose to determine if you are taking too much or to see if you can reduce your dose. He was started on propranolol 60 mg/day and methimazole 20 mg/day. Last updated on Jan 5, 2023. Stop using Methimazole and contact your health practitioner. It made me feel really sluggish but after removal of my thyroid last May I feel lots better and now only take levothyroxine daily. This medication may be used to treat Graves' ophthalmopathy. This content does not have an Arabic version. Eosinophilic myositis may be a feature of multisystem diseases like dermatomyositis, polyarteritis nodosa, and rheumatoid arthritis, but in this case, eosinophilia is rare (4) and the biopsy findings will show prominent vasculitis, which was not present in our case. Blood and urine cultures were negative. Other than anti-thyroid drugs, -blockers have also been implicated in a lupus-like reaction (7), but our patient had complete resolution of symptoms while he was still on -blockers. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider. Mayo Clinic does not endorse companies or products. Center your nutrition around natural unprocessed foods. I recently got the go-ahead to stop taking it and was wondering if I could expect to lose some of the 18 lbs I gained in the year while on the medicine, or whether this is probably my stable weight now that I've . So hang in there as your lab keep normal and you feel good (no or little symptom) Best wishes. Patients who had surgery were not included in the study so we do not have a comparison. The fever subsided. Sometimes its best to go right to the source of the problem and get it taken out and never mind all these prescriptions if you can that is..Hope this helped and hope you get better soon , as I know how tough it is Methimazole is not a steroid. But blocking thyroid production, in a perfect way, is easier said than done. redness of the skin. Take the missed dose as soon as you remember. Methimazole is an antithyroid medication, which means that it works by blocking the production of thyroid hormones. In drug-induced lupus, the symptoms usually appear within a month of starting therapy. Thyroid hormone therapy: patients with hypothyroidism are most often treated with Levothyroxine in order to return their thyroid hormone levels to normal. You may cause more harm than good if you adjust your medication in this way. burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings chest pain chills cough dark urine difficulty in breathing dizziness or lightheadedness drowsiness feeling of constant movement of self or surroundings fever general feeling of discomfort, illness, or weakness headache hoarseness Since my diagnosis of hyper/graves almost 1.5 years ago, I've been on tapazole to control my levels. Hey There! Do not take double or extra doses. Restart Medical LLC. Torlinska B et al 2019 Patients treated for hyperthyroidism are at increased risk of becoming obese: findings from a large prospective secondary care cohort. Low thyroid levels (hypothyroidism)unusual weakness or fatigue, increased sensitivity to cold, constipation, hair loss, dry skin, weight gain, feelings of depression. It is essential to explain Graves disease since it is the leading cause of Hyperthyroidism, and you can use Methimazole to treat it. Follow me on Youtube, Facebook, TikTok, and Instagram for up-to-date thyroid tips, tricks, videos, and more. Wholesomealive is an online healthcare media publishing website. Seven out of 10 people in the U.S. are overweight, many carrying belly fat that is difficult to shed. 3 years ago, Graves disease: the most common cause of hyperthyroidism in the United States. Special care may be needed. Cookie Notice The same is true if you are status post radioactive iodine ablation which is another method of destroying the thyroid gland to treat hyperthyroidism. It is essential to identify the reasons behind weight loss. Murata et al. Weight gain occurred mostly in the first 6 months of treatment but continued until 24 months. These side effects may go away during treatment as your body adjusts to the medicine. Some of the more frequently reported adverse reactions have included skin rash, urticaria, nausea, loss of taste, and abnormal loss of hair. 7 users are following. Comparison group was from the Health Survey for England participants. Several conditions can cause it, including Plummers disease, Graves disease, and thyroiditis. I am a former Doctor of Osteopathic Medicine (no longer practicing) that now focuses on producing the information you see here while also formulating some of the best supplements on the market (in my HUMBLE opinion) :). It absolutely can, and it does this by slowing down your metabolism and reducing the amount of energy that the body produces at baseline. All rights reserved. Do not give this medicine to a child without medical advice. Methimazole was stopped. Need better symptom control? Takiing Armour (thyroid hormone replacement) has seemed to cause your hyperthyroidism. You have to consider that you will be at a disadvantage trying to lose weight if your thyroid is being blocked. Early diagnosis allows prompt withdrawal of the offending drug and resolution of symptoms. Patient information was obtained from Thyroid Clinic Database at the University Hospitals Birmingham NHS Foundation Trust. a beta blocker--atenolol, carvedilol, labetalol, metoprolol, nadolol, propranolol, sotalol, and others. Has anyone experienced weight loss after reducing their methimazole dose? (former Osteopathic Physician). Do not use methimazole in larger or smaller amounts or for longer than recommended. He returned 2 months later for radioactive iodine ablation. This means that general exercise and dieting is usually not sufficient to effect significant weight loss in the person. It is also used before thyroid surgery or radioactive iodine treatment. National Library of Medicine The amount of weight gain was associated with the severity of hyperthyroidism at time of diagnosis and patients who had reported weight loss prior to treatment had more weight gain. New York Times: A Healthy Mix of Rest and Motion. [Ref], Very rare (less than 0.01%): Nephritis[Ref], Frequency not reported: Insulin autoimmune syndrome, Frequency not reported: Vertigo, drug fever[Ref]. A small change in your dose may be sufficient to restore some thyroid function (without causing the symptoms of hyperthyroidism) which can help manage your weight. Over-blocking thyroid hormone may actually take you from hyperthyroidism to hypothyroidism which may then trigger symptoms such as hair loss, weight gain, fatigue, constipation and so on. This risk is slightly higher with RAI therapy compared to medications. While this medication may be prescribed for children for selected conditions, precautions do apply. Eat dark green leafy vegetables like spinach and kale for a calcium boost. Ive put on weight since starting methimazole two years ago. No wonder so many people seem to be talking about Ozempic, an injectable drug approved by the . Exercise regularly. Policy. I love to write and share what I've learned over the years. Learn which foods you should avoid if you have thyroid disease of any type. Ozempic is an FDA-approved prescription medication that has historically been used in treatment plans for type 2 diabetes, however in recent months the drug has been adopted as a way to lose weight.

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